A SET domain-containing protein and HCF-1 maintain transgenerational epigenetic memory
Chenming Zeng, Giulia Furlan, Miguel Vasconcelos Almeida, Juan C. Rueda-Silva, Jonathan L. Price, Helena Santos-Rosa, Jingxiu Xu, Yan Kuang, Enric Cata Socias, Jonas Mars, Pedro Rebelo‐Guiomar, M. R. Huang, Shouhong Guang, Falk Butter, Eric Alexander Miska
This study identifies SET-24, a catalytically inactive SET domain protein in C. elegans, as essential for maintaining transgenerational epigenetic memory through its interaction with HCF-1 and regulation of H3K4me3 levels.
Nature Communications · Jan 9, 2026Peer-reviewedMolecular Biology