Radiosynthesis and preclinical evaluation of a carbon-11 labeled PDE7 inhibitor for PET neuroimaging
Zhiwei Xiao, Jiyun Sun, Masayuki Fujinaga, Huiyi Wei, Chunyu Zhao, Ahmed Haider, Richard S. Van, Tomoteru Yamasaki, Yiding Zhang, Jian Rong, Kuan Hu, Jiahui Chen, Erick Calderon Leon, Atsuto Hiraishi, Junjie Wei, , Steven H. Liang
This paper develops and evaluates [11C]26, a PET probe for imaging PDE7 in the brain, showing promising in vitro performance and moderate specific binding in nonhuman primates.
bioRxiv · Jun 12, 2021 · PreprintNeuroscience