Multiple loci of small effect confer wide variability in efficiency and resistance rate of CRISPR gene drive
Jackson Champer, Zhaoxin Wen, Anisha Luthra, Riona Reeves, Joan Chung, Chen Liu, Yoo Lim Lee, Jingxian Liu, Emily Yang, Philipp W. Messer, Andrew G. Clark
The paper investigates how natural genetic variation affects resistance to CRISPR gene drives in Drosophila, finding that resistance rates vary widely and are polygenic with small-effect loci.
Genetics · Mar 27, 2019Peer-reviewedGenetics