Author

Zhaoxin Wen

Cornell University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 3

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Research Focus:benchmarking· 1 Assay:CRISPR screen· 1 Organism:Drosophila· 1 Approach:experimental assay· 1 Research Focus:GWAS / association mapping· 1

Frequent Co-Authors

Andrew G. ClarkiD· 3 shared Chen LiuiD· 3 shared Jackson ChamperiD· 3 shared Philipp W. MesseriD· 3 shared Emily YangiD· 2 shared Joan Chung· 2 shared Yoo Lim Lee· 2 shared Anisha LuthraiD· 1 shared

Activity by Year

2019-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersGenetics

Andrew G. ClarkORCID

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3 papers

Recent·Most cited

Computational and experimental performance of CRISPR homing gene drive strategies with multiplexed gRNAs

Samuel E. Champer, Suh Yeon Oh, Chen Liu, Zhaoxin Wen, Andrew G. Clark, Philipp W. Messer, Jackson Champer

The paper models CRISPR homing gene drives with multiple gRNAs, finding optimal gRNA numbers and showing their limited standalone effectiveness but value when combined with other strategies.

Science Advances · Mar 4, 2020Peer-reviewedGenetics

Multiple loci of small effect confer wide variability in efficiency and resistance rate of CRISPR gene drive

Jackson Champer, Zhaoxin Wen, Anisha Luthra, Riona Reeves, Joan Chung, Chen Liu, Yoo Lim Lee, Jingxian Liu, Emily Yang, Philipp W. Messer, Andrew G. Clark

The paper investigates how natural genetic variation affects resistance to CRISPR gene drives in Drosophila, finding that resistance rates vary widely and are polygenic with small-effect loci.

Genetics · Mar 27, 2019Peer-reviewedGenetics

Molecular safeguarding of CRISPR gene drive experiments

Jackson Champer, Joan Chung, Yoo Lim Lee, Chen Liu, Emily Yang, Zhaoxin Wen, Andrew G. Clark, Philipp W. Messer

The paper demonstrates synthetic target sites and split drives as safeguarding strategies to prevent unintended spread of CRISPR gene drives from lab to natural populations.

eLife · Jan 21, 2019Peer-reviewedGenetics