Unbiased lineage tracing across the adipose organ decouples developmental origin from anatomical and transcriptomic identities
Oto Inoue, Archana Singh, Meghana Ginugu, Christopher Ahn, Marine A Secchi, Sarah J Bowling, Hee-Woong Lim, Joan Sanchez-Gurmaches
This study uses CRISPR-mediated lineage tracing to show that adipose depot identity is shaped by anatomical niche rather than embryonic lineage.
bioRxiv · Nov 9, 2026 · PreprintDevelopmental Biology