Author

Joana Frobel

RWTH Aachen University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:DNA methylation· 3 Organism:human· 3 Approach:statistical model· 3 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:deconvolution· 1

Frequent Co-Authors

Wolfgang WagneriD· 3 shared Tanja Božić· 2 shared André EsseriD· 1 shared Annamarija Raic· 1 shared Carina Birkhofer· 1 shared Chao-Chung Kuo· 1 shared Claudia WaskowiD· 1 shared Edgar JostiD· 1 shared

Activity by Year

2017-2018 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersGenomics

Wolfgang WagnerORCID

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3 papers

Recent·Most cited

Epigenetic aging of human hematopoietic cells is not accelerated upon transplantation into mice

Joana Frobel, Susann Rahmig, Julia Franzen, Claudia Waskow, Wolfgang Wagner

The paper shows that human hematopoietic cells maintain normal epigenetic development patterns when transplanted into mice, and epigenetic aging does not accelerate in the xenogeneic environment.

Clinical Epigenetics · May 22, 2018Peer-reviewedGenomics

Variants of DNMT3A cause transcript-specific DNA methylation patterns and affect hematopoietic differentiation

Tanja Božić, Joana Frobel, Annamarija Raic, Fabio Ticconi, Chao-Chung Kuo, Stefanie Heilmann-Heimbach, Tamme W. Goecke, Martin Zenke, Edgar Jost, Ivan G. Costa, Wolfgang Wagner

This study shows that specific DNMT3A transcripts have distinct epigenetic and functional effects on hematopoietic differentiation and are linked to AML outcomes.

bioRxiv · May 9, 2018 · PreprintCell Biology

Leukocyte counts based on site-specific DNA methylation analysis

Joana Frobel, Tanja Božić, Michael Lenz, Peter Uciechowski, Yang Han, Reinhild Herwartz, Klaus Strathmann, Susanne Isfort, Jens Panse, André Esser, Carina Birkhofer, Uwe Gerstenmaier, Thomas Kraus, Lothar Rink, Steffen Koschmieder, Wolfgang Wagner

The paper develops a method to estimate leukocyte counts using DNA methylation analysis, achieving similar precision to conventional methods with advantages in sample handling.

Clinical Chemistry · Nov 8, 2017Peer-reviewedMolecular Biology