Carcinogen-induced preinvasive human squamous lung cancer is characterised by a novel atypical basal cell state and presents opportunities for chemoprevention
Wenrui Guo, Holly A. R. Giles, Alice Chernaik, Yasin Memari, Joanna Xie, Daniella Black, Anne Hilgendorff, Christina Gabriel, Ali Önder Yildirim, Helen Davies, Martin Goddard, Lauren D’Sa, Otmar Schmid, Serena Nik‐Zainal, Namshik Han, Frank M. McCaughan
This study develops a human model of early squamous lung cancer induced by a carcinogen, identifies a novel atypical basal cell state, and shows that capivasertib prevents and reverses the abnormal phenotype.
bioRxiv · Sep 18, 2026 · PreprintCancer Biology