Otmar Schmid

Carcinogen-induced preinvasive human squamous lung cancer is characterised by a novel atypical basal cell state and presents opportunities for chemoprevention

This study develops a human model of early squamous lung cancer induced by a carcinogen, identifies a novel atypical basal cell state, and shows that capivasertib prevents and reverses the abnormal phenotype.

Alveolar macrophages initiate the spatially targeted neutrophil recruitment during nanoparticle inhalation

The paper shows that alveolar macrophages recruit neutrophils to sites of nanoparticle deposition in the lung through motility, phagocytosis, and cytokine release.

From the Roundabout of Molecular Events to Nanomaterial-Induced Chronic Inflammation Prediction

The paper predicts nanomaterial-induced chronic inflammation using in vitro measurements and in silico modeling by identifying mechanisms of nanomaterial cycling and quarantining in lung cells.