Substrate stiffness modulates the emergence and magnitude of senescence phenotypes in dermal fibroblasts
Bartholomew Starich, Fan Yang, Derin Tanrioven, Heng‐Chung Kung, Joanne Baek, Praful R. Nair, Pratik Kamat, Nicolas C. Macaluso, Joon H. Eoh, Kyu Sang Han, Luo Gu, Jeremy D Walston, Sean X. Sun, Pei‐Hsun Wu, Denis Wirtz, Jude M. Phillip
This study shows that substrate stiffness affects the development and strength of senescence features in fibroblasts, with mechanosensitive regulation of key biomarkers.
bioRxiv · Feb 6, 2024 · PreprintMolecular Biology