A neuron-specific microexon ablates the novel DNA-binding function of a histone H3K4me0 reader PHF21A
Robert S. Porter, Sojin An, María Cecilia Gavilán, Masayoshi Nagai, Yumie Murata-Nakamura, Bo O. Zhou, Katherine M. Bonefas, Olivier Dionne, Jeru Manoj Manuel, Joannie St-Germain, Suzanne Gascon, Jacqueline I. Kim, Liam Browning, Benoît Laurent, Uhn‐Soo Cho, Shigeki Iwase
The paper identifies neuron-specific microexon splicing in chromatin regulators, showing that PHF21A loses DNA-binding function in neurons while retaining H3K4me0 recognition, contributing to brain development.
Cell Reports · Jan 1, 2025Peer-reviewedMolecular Biology