Author

Joel T. Sydzyik

Kansas State University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:C. elegans· 2 Approach:experimental assay· 2 Assay:CRISPR screen· 1 Organism:human· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Anna ZinovyevaiD· 2 shared Jeffrey C. MedleyiD· 2 shared Christopher M. HammelliD· 1 shared Ganesh Prabhakar PanzadeiD· 1 shared Heather Crawshaw· 1 shared Huiwu Ouyang· 1 shared Mira BhandariiD· 1 shared Sarah Y. Zhang· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersMolecular Biology

Anna ZinovyevaORCID

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2 papers

Recent·Most cited

Molecular BiologybioRxivPreprintOct 15, 2025

3' Nucleotide Asymmetry Directs miRNA Strand Selection

Jeffrey C. Medley, Sumire Kurosu Moriya, Huiwu Ouyang…·Anna Zinovyeva

The paper identifies 3' nucleotide asymmetry as a key factor in miRNA strand selection, showing its role in guiding the loading of the guide strand into miRISC in C. elegans and human cells.

DOI 10.1101/2025.10.15.682714

C. eleganshuman

𝕏 PostBluesky

GeneticsGeneticsPeer-reviewedNov 15, 2021

Single Nucleotide Substitutions Effectively Block Cas9 and Allow for Scarless Genome Editing in Caenorhabditis elegans

Jeffrey C. Medley, Shilpa Hebbar, Joel T. Sydzyik, Anna Zinovyeva

This study shows that single-nucleotide substitutions in the guide sequence block Cas9 activity in C. elegans, enabling efficient genome editing without additional blocking mutations.

9 citations

C. elegansCRISPR screen

𝕏 PostBluesky