Sean Michael Grimmond

This study identifies genomic mechanisms enabling BRCA1 methylation loss and promoter bypass in ovarian cancer, leading to PARP inhibitor resistance.

RNAsum integrates WGS and WTS data to improve cancer diagnostics by corroborating clinically relevant variants and supporting therapeutic decisions.

This study compares proliferation and tolerance in tissue-resident and recruited macrophages using single-cell RNA sequencing, finding that proliferative capacity differs between cell types.