Mechanical Centrosome Fracturing during Cell Navigation
Madeleine T. Schmitt, Janina Kroll, Mauricio J.A. Ruiz-Fernandez, Robert Hauschild, Shaunak Ghosh, Petra Kameritsch, Jack Merrin, Johanna Schmid, Kasia Stefanowski, Andreas W. Thomae, Jingyuan Cheng, Gamze Naz Öztan, Peter Konopka, Germán Camargo Ortega, Thomas Penz, , Jörg Renkawitz
The paper shows that centrosomes in non-dividing cells can fracture under mechanical stress during cell navigation, and Dyrk3 prevents this fracturing to maintain cellular function.
Science Advances · Apr 25, 2025Peer-reviewedCell Biology