Jack Merrin

Substrate heterogeneity promotes cancer cell dissemination through interface roughening

This study shows that substrate disorder promotes single-cell cancer invasion, comparable to cadherin loss, by altering invasion dynamics through spatial heterogeneity.

Simulation-Based Inference of Cell Migration Dynamics in Complex Spatial Environments

The paper uses a Cellular Potts model and neural posterior estimation to infer cell migration dynamics in microfabricated environments, showing improved parameter inference over classical methods.

Global coordination of protrusive forces in migrating immune cells

This study shows how immune cells adjust their actin dynamics in dense environments to navigate through tissue by shifting their nucleus position and coordinating protrusive forces.

Mechanical Centrosome Fracturing during Cell Navigation

The paper shows that centrosomes in non-dividing cells can fracture under mechanical stress during cell navigation, and Dyrk3 prevents this fracturing to maintain cellular function.

Size-Dependent Mechanoadaptation Enables Migration with Oversized Parasitic Cargo

The paper investigates how cells adapt to transport oversized parasitic cargo by reprogramming mechanical forces and subcellular architecture during migration.

Fabrication of elastomeric stencils for patterned stem cell differentiation

This paper describes a method to create elastomeric stencils for controlled stem cell differentiation and pattern formation.

Self-organised pattern formation in the developing neural tube by a temporal relay of BMP signalling

The paper studies BMP signalling dynamics in the developing neural tube, showing temporal relay mechanisms drive self-organised cell type patterns.