Erosion of the Epigenetic Landscape and Loss of Cellular Identity as a Cause of Aging in Mammals
Jae-Hyun Yang, Patrick T. Griffin, Daniel L. Vera, John K. Apostolides, Motoshi Hayano, Margarita V. Meer, Elias Salfati, Qiao Su, Elizabeth M. Munding, Marco Blanchette, Mital S. Bhakta, Zhixun Dou, Caiyue Xu, Jeffrey W. Pippin, Michael L. Creswell, , David A. Sinclair
The paper shows that inducing DNA breaks accelerates aging-related chromatin changes and loss of cell identity in mammals.
bioRxiv · Oct 19, 2019 · PreprintMolecular Biology