TRMT10A deficiency and tRNA fragmentation disrupt human pancreatic β-cell identity and insulin maturation
Cristina Moreno‐Castro, María Nicol Arroyo, Khadija Benabdallah, Ane Olazagoitia‐Garmendia, Bruno J. Santacreu, Toshiaki Sawatani, Jonathan Green, Nathalie Pachera, Cristina Cosentino, David Communi, Xavier Bisteau, Virginie Imbault, Soumi Srimani, Jarne Pauwels, Kris Gevaert, , Mariana Igoillo‐Esteve
This study shows TRMT10A deficiency causes β-cell dysfunction by promoting tRNA fragmentation and disrupting PCSK1 expression, leading to impaired insulin maturation and glucose-stimulated insulin secretion.
bioRxiv · Jul 23, 2026 · PreprintMolecular Biology