Mariana Igoillo‐Esteve

TRMT10A deficiency and tRNA fragmentation disrupt human pancreatic β-cell identity and insulin maturation

This study shows TRMT10A deficiency causes β-cell dysfunction by promoting tRNA fragmentation and disrupting PCSK1 expression, leading to impaired insulin maturation and glucose-stimulated insulin secretion.

The type 1 diabetes-associated lncRNA ARGI participates in virus-induced pancreatic beta cell inflammation.

This study identifies the lncRNA ARGI as a mediator of virus-induced inflammation in pancreatic beta cells linked to type 1 diabetes through allele-specific transcriptional activation.

A functional genomic approach to identify reference genes for human pancreatic beta cell real-time quantitative RT-PCR analysis

The paper identifies stable reference genes for normalizing gene expression in human pancreatic beta cells under stress conditions using RNA-seq and qPCR validation.