Increased Expression and Altered Functional Activities of Immune Receptors TREM1, PD-L1, and Others on Hematopoietic Progenitor Cells in a Mouse Model of Rheumatoid Arthritis
Johanna M Toth, Roselyn R. Jiang, Lin Tze Tung, Dania Shaban, Mathieu Mancini, Bianca Pozzebon, Joo Eun Kim, Mitra Yousefi, Danielle Malo, Silvia Marina Vidal, Inés Colmegna, David Langlais, Anastasia Nijnik
This study shows that immune receptors on hematopoietic progenitor cells are upregulated in a mouse model of rheumatoid arthritis and that stimulating these receptors alters cell expansion and differentiation.
bioRxiv · Jun 12, 2026 · PreprintImmunology