Gilles Charvin

Pathological mitochondrial dysfunction mimics an aging pathway in budding yeast

The paper shows that mitochondrial dysfunction in budding yeast mimics aging by causing a state with low membrane potential and heme loss, affecting both young and old cells.

Both Genome Instability and Replicative Senescence Stem from the Shortest Telomere in Telomerase-Negative Cells

The paper identifies a threshold telomere length in telomerase-negative cells that triggers replicative senescence and genomic instability through dysfunction of the shortest telomere.

Regulation of cell proliferation by a novel feedback system on Cdk function

This study identifies a novel feedback system regulating Cdk function through Spo12, a small disordered protein that inhibits PP2A, and shows its role in enhancing cell proliferation in fission yeast.

COSPLAY: An expandable toolbox for combinatorial and swift generation of expression plasmids in yeast

COSPLAY provides a modular, expandable toolbox for generating yeast expression plasmids using a Golden Gate approach and software-assisted protocol.

Nucleolar stress causes the entry into replicative senescence in budding yeast

This study shows that nucleolar stress from ERC accumulation causes replicative senescence in budding yeast, but not in long-lived fob1{triangleup} mutant cells.