Béla Novák

This study identifies a new role for Wee1 in promoting S-phase entry by inhibiting APC/CCdh1, revealing a mechanism that impacts the efficacy and toxicity of Wee1 inhibitors in cancer treatment.

This study identifies a novel feedback system regulating Cdk function through Spo12, a small disordered protein that inhibits PP2A, and shows its role in enhancing cell proliferation in fission yeast.

The paper develops a dynamical model of the cell cycle as two mutually inhibitory oscillators, showing how this framework can explain various cell cycle behaviors.

The paper analyzes experimental data on fission yeast cell cycle transitions and proposes a stochastic model to assess bistability of the G2/M checkpoint.

This paper shows that dysregulation of CycB:CDK disrupts cell cycle switches, leading to genome doubling, a common event in tumorigenesis.

This paper develops a rule-based cell cycle model for RPE-1 cells that explains 16 observables and improves model reusability through PEtab specification.

The paper shows that mitotic kinase oscillations control cell cycle latches, and disrupting these leads to endocycles in yeast.

The paper develops a computational model to explain DNA re-replication in fission yeast mutants, showing how protein overproduction leads to transitions between endoreplication and over-replication.

The paper identifies a generic network motif of coupled positive and negative feedback loops governing bistable transitions in the eukaryotic cell cycle.

This study uses mathematical models to investigate size control mechanisms in budding yeast, finding that titration of Cln3 against genomic binding sites provides a more accurate explanation than inhibitor dilution.