Spatial profiling of chromatin accessibility reveals alteration of glial cells in Alzheimer's disease mouse brain
Dehui Kong, Hongjie He, Joseph Lechner, Jing Yang, Aijun Zhang, Ling Li, Ramkumar Mathur, Diane C. Darland, Motoki Takaku, L. Lü, Junmin Peng, Kai Yang, Xusheng Wang
The paper uses spatial ATAC-seq to identify chromatin accessibility changes in glial cells of Alzheimer's disease mouse models, linking them to AD-related pathways and human risk genes.
bioRxiv · May 1, 2025 · PreprintBioinformatics