Motoki Takaku

Inhibition of p38-MK2 pathway enhances the efficacy of microtubule inhibitors in breast cancer cells

This study shows that inhibiting the p38-MK2 pathway enhances the effectiveness of microtubule inhibitors in breast cancer cells while sparing normal cells.

Spatial profiling of chromatin accessibility reveals alteration of glial cells in Alzheimer's disease mouse brain

The paper uses spatial ATAC-seq to identify chromatin accessibility changes in glial cells of Alzheimer's disease mouse models, linking them to AD-related pathways and human risk genes.

One step 4x and 12x 3D-ExM: robust super-resolution microscopy in cell biology

This study introduces 4x and 12x 3D-ExM methods for super-resolution microscopy, achieving nanometer-scale resolution for visualizing cellular structures.

Genomic transcription factor binding site selection is edited by the chromatin remodeling factor CHD4

This study shows CHD4 prevents inappropriate gene activation by editing transcription factor binding site selection through chromatin remodeling in breast cancer cells and during reprogramming.

GATA3 mutation disrupts a functional network governed by estrogen receptor, FOXA1 and GATA3

This study investigates how a GATA3 mutation affects the transcriptional network involving ER, FOXA1, and GATA3, showing disrupted cooperation and altered chromatin localization.