Xusheng Wang

Acute opioid responses are modulated by dynamic interactions of Oprm1 and Fgf12

This study identifies time-dependent epistatic interactions between Oprm1 and Fgf12 that modulate opioid-induced locomotion in mice and links Fgf12 to opioid behavior in humans.

Large-scale integration of omics and electronic health records to identify potential risk protein biomarkers and therapeutic drugs for cancer prevention

This study integrates large-scale omics and electronic health records to identify risk proteins and drugs for cancer prevention, finding 101 novel proteins and three drugs associated with reduced colorectal cancer risk.

Spatial profiling of chromatin accessibility reveals alteration of glial cells in Alzheimer's disease mouse brain

The paper uses spatial ATAC-seq to identify chromatin accessibility changes in glial cells of Alzheimer's disease mouse models, linking them to AD-related pathways and human risk genes.

Non-invasive diagnosis of early chronic colitis cancerization via amplified sensing of miRNA-21 in NIR-IIb window

This paper develops a non-invasive method to detect early chronic colitis cancerization by amplifying miRNA-21 sensing in the NIR-IIb window, enabling detection up to 4 weeks before biopsy.

OTULIN Interactome Reveals Immune Response and Autophagy Associated with Tauopathy in a Mouse Model

The paper analyzes the OTULIN interactome in PS19 transgenic and non-transgenic mice to identify proteins involved in immune response and autophagy associated with tauopathy.

CPT1A Mediates Radiation Sensitivity in Colorectal Cancer

This study identifies CPT1A as a mediator of radiation sensitivity in colorectal cancer, showing its role in ROS scavenging and DNA damage response through the FOXM1-SOD1/SOD2/CAT axis.