Regulation of neuroinflammation by astrocyte-derived cholesterol.
Hao Wang, Joshua A. Kulas, Yang Yu, Joshua L. Milstein, Claire E. Peng, Holden Higginbotham, Jed Robert Christensen, Michael A. Kovacs, Anton M. Schüle, Denys Oliinyk, Thierry M. Nordmann, Matthias Mann, Adriano Aguzzi, Heather Anne Ferris, Scott B. Hansen
This study shows that astrocyte-derived cholesterol, released via apoE, promotes neuroinflammation by enhancing inflammatory signaling in immune cells.
bioRxiv · Dec 12, 2022 · PreprintNeuroscience