Chlorotonils exhibit potent activity against Mycobacterium tuberculosis, while resistance is mediated by MmpR5-MmpL5
Felix Deschner, Melissa Dalcina Chengalroyen, Lauren Ames, Diana Quach, Rodrigo Aguilera Olvera, Barbara Bosch, Anthony Castro, Heather Kim, Karthik Raman, Natalie Thornton, Joshua Wallach, Fernanda Rodrigues da Costa, R. H. Allen, Andréanne Lupien, Mandisa Zuma, , Jennifer E. Herrmann
This study identifies chlorotonils as potent anti-Mtb agents and shows resistance is mediated by MmpR5-MmpL5.
bioRxiv · Dec 10, 2025 · PreprintMicrobiology