Author

Mandisa Zuma

University of Cape Town

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:whole-genome sequencing· 2 Organism:bacteria (other)· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1

Frequent Co-Authors

Melissa Dalcina ChengalroyeniD· 2 shared Valerie MizrahiiD· 2 shared Andréanne LupieniD· 1 shared Aneta H. WorleyiD· 1 shared Anthony CastroiD· 1 shared Barbara BoschiD· 1 shared Carolina MehaffyiD· 1 shared David Michael LewinsohniD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersMicrobiology

Melissa Dalcina ChengalroyenORCID

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2 papers

Recent·Most cited

Chlorotonils exhibit potent activity against Mycobacterium tuberculosis, while resistance is mediated by MmpR5-MmpL5

Felix Deschner, Melissa Dalcina Chengalroyen, Lauren Ames, Diana Quach, Rodrigo Aguilera Olvera, Barbara Bosch, Anthony Castro, Heather Kim, Karthik Raman, Natalie Thornton, Joshua Wallach, Fernanda Rodrigues da Costa, R. H. Allen, Andréanne Lupien, Mandisa Zuma, , Jennifer E. Herrmann

This study identifies chlorotonils as potent anti-Mtb agents and shows resistance is mediated by MmpR5-MmpL5.

bioRxiv · Dec 10, 2025 · PreprintMicrobiology

Disruption of riboflavin biosynthesis in mycobacteria establishes 5-amino-6-D-ribitylaminouracil (5-A-RU) as key precursor of MAIT cell agonists

Melissa Dalcina Chengalroyen, Nurudeen Oketade, Aneta H. Worley, Megan Lucas, Luisa María Nieto Ramírez, Mabule L. Raphela, Gwendolyn M. Swarbrick, Paul S. Soma, Mandisa Zuma, Digby Francis Warner, Deborah A. Lewinsohn, Carolina Mehaffy, Erin J. Adams, William H. Hildebrand, Karen M. Dobos, , David Michael Lewinsohn

Deleting early riboflavin genes (ribA2 in both species, ribG in M. smegmatis) sharply reduced MAIT cell activation, while ribH deletion raised recognition of M. tuberculosis only.

PLoS Pathogens · Jul 1, 2025Peer-reviewedImmunology✦ In-depth digest