PNPLA3-I148M is a Neomorph that Interferes with Two Primary Hepatic Triglyceride Clearance Pathways
David J. Sherman, Lei Liu, Edward L. LaGory, Preston Fordstrom, Danielle Pruitt, Jose Barreda, Joy G. Cagmat, Jiansong Xie, John Ferbas, Ingrid C. Rulifson, Raymond J. Deshaies
This paper identifies PNPLA3-I148M as a neomorphic variant that impairs ApoB secretion and lipid metabolism, contributing to fatty liver disease.
Cell Reports · Oct 1, 2025Peer-reviewedCell Biology