Author

Jiansong Xie

Amgen (United States)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1

Frequent Co-Authors

Anh T. Tran· 1 shared Arghya Sadhukhan· 1 shared Brian A. LanmaniD· 1 shared Chris Wilde· 1 shared Christopher E. SmithiD· 1 shared Danielle PruittiD· 1 shared David J. ShermaniD· 1 shared Dhanusha A. NalawanshaiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperCancer Biology

Anh T. Tran

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

PNPLA3-I148M is a Neomorph that Interferes with Two Primary Hepatic Triglyceride Clearance Pathways

David J. Sherman, Lei Liu, Edward L. LaGory, Preston Fordstrom, Danielle Pruitt, Jose Barreda, Joy G. Cagmat, Jiansong Xie, John Ferbas, Ingrid C. Rulifson, Raymond J. Deshaies

This paper identifies PNPLA3-I148M as a neomorphic variant that impairs ApoB secretion and lipid metabolism, contributing to fatty liver disease.

Cell Reports · Oct 1, 2025Peer-reviewedCell Biology

LYMTACs: Chimeric Small Molecules Repurpose Lysosomal Membrane Proteins for Target Protein Relocalization and Degradation

Dhanusha A. Nalawansha, Georgios Mazis, Gitte Husemoen, Kate S. Ashton, Weixian Deng, Ryan P. Wurz, Anh T. Tran, Brian A. Lanman, Jiansong Xie, Robert G. Guenette, Shiqian Li, Christopher E. Smith, Suresh Archunan, Manoj K. Agnihotram, Arghya Sadhukhan, , Patrick Ryan Potts

This paper introduces LYMTACs, small molecules that use lysosomal membrane proteins to target and degrade membrane proteins, showing effectiveness against KRASG12D.

Nature Communications · Aug 21, 2025Peer-reviewedCancer Biology