Author

John Ferbas

Amgen (United States)ORCID 0000-0003-4087-4629Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1 Organism:mouse· 1

Frequent Co-Authors

Aniruddha SahasrabuddheiD· 1 shared Danielle PruittiD· 1 shared David J. ShermaniD· 1 shared Edward L. LaGoryiD· 1 shared Ingrid C. RulifsoniD· 1 shared Jiansong Xie· 1 shared John O. HuiiD· 1 shared Jose BarredaiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperBiochemistry

Aniruddha SahasrabuddheORCID

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2 papers

Recent·Most cited

Cell BiologyCell ReportsPeer-reviewedOct 1, 2025

PNPLA3-I148M is a Neomorph that Interferes with Two Primary Hepatic Triglyceride Clearance Pathways

David J. Sherman, Lei Liu, Edward L. LaGory…·Raymond J. Deshaies

This paper identifies PNPLA3-I148M as a neomorphic variant that impairs ApoB secretion and lipid metabolism, contributing to fatty liver disease.

9 citationstop 3%

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BiochemistrybioRxivPreprintJun 16, 2025

Novel mechanistic insights for catalytic bioluminescence of mammalian Gaussia Luciferase through mutant and ancestral analysis

Raina M. Borum, Michael B. Lanzillotti, Aniruddha Sahasrabuddhe…·John Ferbas

This study investigates the catalytic mechanism of Gaussia Luciferase through mutant and ancestral analysis, revealing methionine oxidation's role in luminescence and evolutionary changes in substrate turnover.

1 citation

proteomicsexperimental assay

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