Vertical RAS-pathway inhibition in pancreatic cancer drives therapeutically exploitable mitochondrial alterations
Philipp Hafner, Steffen Johannes Keller, Xun Chen, Asma Y. Alrawashdeh, Huda Jumaa, Friederike Inga Nollmann, Solène Besson, Judith Kemming, Oliver Gorka, Tonmoy Das, Bismark Appiah, Ariane Lehmann, Mujia Jenny Li, Petya Apostolova, Bertram Bengsch, , Dietrich Alexander Ruess
This study shows that dual SHP2/MEK inhibition in pancreatic cancer causes mitochondrial changes and ROS elevation, leading to a therapy-resistant state that can be targeted with GPX4 inhibition.
Signal Transduction and Targeted Therapy · Jan 16, 2026Peer-reviewedCancer Biology