This study shows that dual SHP2/MEK inhibition in pancreatic cancer causes mitochondrial changes and ROS elevation, leading to a therapy-resistant state that can be targeted with GPX4 inhibition.

Signal Transduction and Targeted Therapy · Jan 16, 2026Peer-reviewedCancer Biology

In Situ, Antibody-Independent, and Multiplexed Characterization of Amyloid Plaques by MALDI MS/MS Imaging Using iprm-PASEF

Larissa Chiara Meyer, Mujia Jenny Li, Nadine Meier, Beate Vollmer-Kary, Tobias Feilen, Julie Audebert, Konrad Kurowski, Stephan Singer, Peter Bronsert, Melanie Christine Föll, Oliver Schilling

This study demonstrates the use of iprm-PASEF for in situ, antibody-independent, and multiplexed characterization of amyloid plaques in tissue samples.

Analytical and Bioanalytical Chemistry · Jan 14, 2026Peer-reviewedMolecular Biology

Spatial Proteomics By Parallel Accumulation-Serial Fragmentation Supported MALDI MS/MS Imaging: A First Glance Into Multiplexed and Spatial Peptide Identification

Mujia Jenny Li, Larissa Chiara Meyer, Nadine Meier, Jannik Witte, Maximilian Maldacker, Adrianna Seredynska, Julia B. Schüler, Oliver Schilling, Melanie Christine Föll

This paper introduces a novel MALDI imaging method combining TIMS-PASEF for multiplexed and spatial peptide identification in tissue samples.

Rapid Communications in Mass Spectrometry · Feb 5, 2025Peer-reviewedBiochemistry