Senataxin is required for optimal class switch recombination to the immunoglobulin A isotype
Vithushan Surendran, Jonathan Mapletoft, Peter YF. Zeng, Julia Avolio, Sam Afkhami, Joshua J.C. McGrath, Andrew T. Chen, Art Marzok, Jann Catherine Ang, Kyle Amaral, Yona Tugg, Martin R. Stämpfli, Matthew S. Miller
This study shows that senataxin deficiency impairs class switch recombination to IgA in vitro, reduces IgA response to infection, and decreases IgA repertoire diversity in vivo.
bioRxiv · Sep 23, 2025 · PreprintImmunology