Loss of Prm1 leads to defective chromatin protamination, impaired PRM2 processing, reduced sperm motility and subfertility in male mice
Gina Esther Merges, Julia C. Meier, Simon Schneider, Alexander Kruse, Andreas Christian Fröbius, Gregor Kirfel, Klaus Steger, Lena Arévalo, Hubert Schorle
This study shows that Prm1 deficiency in mice causes DNA damage, impaired PRM2 processing, and subfertility due to disrupted chromatin protamination.
Development · May 24, 2022Peer-reviewedDevelopmental Biology