Author

Alexander Kruse

Justus-Liebig-Universität GießenORCID 0000-0001-5526-9347Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Assay:proteomics· 3 Research Focus:differential expression· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Hubert SchorleiD· 3 shared Klaus StegeriD· 3 shared Simon SchneideriD· 3 shared Andreas Christian FröbiusiD· 2 shared Gina Esther MergesiD· 2 shared Lena ArévaloiD· 2 shared Andreas BuneßiD· 1 shared Ansgar PoetschiD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersMolecular Biology

Hubert SchorleORCID

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3 papers

Recent·Most cited

Molecular BiologyMolecular Human ReproductionPeer-reviewedJan 1, 2025

An aberrant protamine ratio is associated with decreased H4ac levels in murine and human sperm

Alexander Kruse, Simon Schneider, Gina Esther Merges…·Klaus Steger

The paper investigates the relationship between protamine ratios and histone acetylation levels in sperm from mice and humans, finding reduced H4ac levels associated with altered protamine ratios.

2 citations

mousehuman

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Developmental BiologyDevelopmentPeer-reviewedMay 24, 2022

Loss of Prm1 leads to defective chromatin protamination, impaired PRM2 processing, reduced sperm motility and subfertility in male mice

Gina Esther Merges, Julia C. Meier, Simon Schneider…·Hubert Schorle

This study shows that Prm1 deficiency in mice causes DNA damage, impaired PRM2 processing, and subfertility due to disrupted chromatin protamination.

54 citationstop 1%

mouseproteomics

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Molecular BiologyCellsPeer-reviewedJul 27, 2020

Prm2 deficiency triggers a Reactive Oxygen Species (ROS)-mediated destruction cascade during epididymal sperm maturation in mice

Simon Schneider, Farhad Shakeri, Christian Trötschel…·Hubert Schorle

This study investigates Prm2 deficiency in mice, showing it leads to oxidative stress and DNA damage during sperm maturation, affecting fertility.

44 citationstop 4%

mouseproteomics

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