Fasting is required for many of the benefits of calorie restriction in the 3xTg mouse model of Alzheimer&aposs disease
Reji Babygirija, Jessica H. Han, Michelle M. Sonsalla, Ryan Matoska, Mariah F. Calubag, Cara L. Green, Anna Tobon, Chung‐Yang Yeh, Diana Vertein, Sophia Schlorf, Julia Illiano, Yang Liu, Isaac Grunow, Michael J. Rigby, Luigi Puglielli, , Dudley W. Lamming
This study shows that fasting, not just calorie reduction, is necessary for many benefits of caloric restriction in 3xTg mice with Alzheimer's disease.
Nature Communications · Aug 4, 2025Peer-reviewedPhysiology