Michael J. Rigby

Restriction of individual branched-chain amino acids has distinct effects on the development and progression of Alzheimers disease in 3xTg mice

This study examines the effects of restricting individual branched-chain amino acids on Alzheimer's disease progression in 3xTg mice, finding sex-specific cognitive and metabolic benefits.

Fasting is required for many of the benefits of calorie restriction in the 3xTg mouse model of Alzheimer&aposs disease

This study shows that fasting, not just calorie reduction, is necessary for many benefits of caloric restriction in 3xTg mice with Alzheimer's disease.

Acarbose ameliorates Western diet-induced metabolic and cognitive impairments in the 3xTg mouse model of Alzheimer's disease

This study shows acarbose improves metabolic health and reduces cognitive deficits in Western diet-fed 3xTg mice, suggesting it may help prevent or delay Alzheimer's disease.