Genome-wide cell type-specific and sex-specific transcriptional dysregulation in the islet of Langerhans underlies islet dysfunction in Down syndrome-related diabetes
Cyrus R. Sethna, Maria Del Carmen Mendoza Niemes, Bayley J. Waters, Matthew R. Wagner, Jacob Smith, Sutichot D. Nimkulrat, Julia Lemanski, Nicolas G Pintozzi, Valentina Lo Sardo, Barak Blum
The paper identifies cell type-specific and sex-specific transcriptional dysregulation in islets of Langerhans in Down syndrome mice, linking it to increased T2D risk.
bioRxiv · Mar 16, 2026 · PreprintDevelopmental Biology