Matthew R. Wagner

Stromal and Neuronal Sources of Slit2/3 Ligands in the Adult Pancreas Exhibit Distinct Expression Patterns Independent of Robo2 Receptor Expression in the Islet

The paper identifies distinct cellular sources of Slit2/3 in the adult pancreas and shows their expression dynamics are independent of Robo2 receptor expression in islet cells.

Genome-wide cell type-specific and sex-specific transcriptional dysregulation in the islet of Langerhans underlies islet dysfunction in Down syndrome-related diabetes

The paper identifies cell type-specific and sex-specific transcriptional dysregulation in islets of Langerhans in Down syndrome mice, linking it to increased T2D risk.

Islet architecture in adult mice is actively maintained by Robo2 expression in beta cells

This study shows that Robo2 in adult beta cells actively maintains islet architecture, as its deletion leads to loss of architecture without affecting beta cell identity or function.