Human Anti-Glycan Reactivity is Driven by the Selection of B cells Utilizing Private Antibody Gene Rearrangements that are Affinity Maturated in Germinal Centers
J. Stewart New, Christopher Fucile, Amanda R. Callahan, Julia N. Burke, Randall S. Davis, Wayne L. Duck, Alexander F. Rosenberg, John F. Kearney, Rodney Glenn King
The paper analyzes the human anti-GlcNAc B cell repertoire using BCR cloning and single-cell transcriptomics, finding germinal center-driven affinity maturation and diverse glycan specificity.
Immunity · Mar 1, 2026Peer-reviewedImmunology