SMN-primed ribosomes modulate the translation of transcripts related to Spinal Muscular Atrophy
Fabio Lauria, Paola Bernabò, Toma Tebaldi, Ewout J. N. Groen, Elena Perenthaler, Federica Maniscalco, Annalisa Rossi, Deborah Donzel, Massimiliano Clamer, Marta Marchioretto, Neža Omersa, Julia Orri, Mauro Dalla Serra, Gregor Anderluh, Alessandro Quattrone, , Gabriella Viero
The paper shows SMN protein binds ribosomes and modulates translation of specific mRNAs in SMA, causing translational defects in motor neuron-related proteins.
Nature Cell Biology · Sep 21, 2020Peer-reviewedNeuroscience