Alessandro Quattrone

Centrosome architecture and m6A-dependent gating of p53 surveillanceafter whole-genome doubling

The paper investigates how centrosome architecture and m6A-dependent regulation influence p53 surveillance after whole-genome doubling, identifying key molecular mechanisms.

Unveiling Oligodendrocyte-Lineage Differentiation in the Glioblastoma Infiltrative Zone Through Spatial Transcriptomics

This study uses spatial transcriptomics to show that infiltrative glioblastoma cells differentiate toward an oligodendrocyte-like state, which may contribute to tumor invasion and recurrence.

Disruption of ribosome dynamics and mRNA homeostasis triggers a cascading imbalance in protein synthesis in models of Amyotrophic Lateral Sclerosis

This study investigates how TDP-43 dysregulation disrupts protein synthesis in ALS models by altering ribosome dynamics and mRNA homeostasis, revealing a conserved mechanism across in vitro and in vivo systems.

CD81-guided heterologous EVs present heterogeneous interactions with breast cancer cells

The paper investigates how CD81-guided extracellular vesicles interact with breast cancer cells and deliver cargo, showing HER2 receptor influence on tropism and drug efficacy.

The three YTHDF paralogs and VIRMA are the major tumor drivers among the m6A core genes in a pan-cancer analysis

This study identifies YTHDF paralogs and VIRMA as major tumor drivers among m6A core genes through a pan-cancer analysis of 10,000 samples.

Inexpensive and colorimetric RNA detection by E. coli cell-free protein synthesis platform at room temperature

This paper describes a low-cost, colorimetric method for detecting SARS-CoV-2 RNA using E. coli cell-free protein synthesis at room temperature.

SMN-primed ribosomes modulate the translation of transcripts related to Spinal Muscular Atrophy

The paper shows SMN protein binds ribosomes and modulates translation of specific mRNAs in SMA, causing translational defects in motor neuron-related proteins.

The m6A reader Ythdf restricts axonal growth in Drosophila through target selection modulation of the Fragile X mental retardation protein

This study shows that the m6A reader Ythdf limits axonal growth in Drosophila by modulating Fmr1 target selection.

p53-induced apoptosis is specified by a translation program regulated by PCBP2 and DHX30.

This study identifies a translational control mechanism regulated by PCBP2 and DHX30 that determines the outcome of p53 activation by Nutlin, shifting the response from cell cycle arrest to apoptosis.

The architecture of the human RNA-binding protein regulatory network

The paper identifies two structural features of the RBP-RBP regulatory network: RBP clusters and RBP chains, which together enable coordinated control of gene expression.

Hypomorphic mutation of the mouse Huntingtons disease gene orthologue

This study investigates the developmental effects of hypomorphic mutations in the mouse HD gene orthologue, revealing varying degrees of lethality and developmental abnormalities depending on mutation severity.

An homeotic post-transcriptional network controlled by the RNA-binding protein RBMX

The paper identifies 5HCEs in human 5UTRs, finds they are enriched in homeotic genes, and shows RBMX regulates these genes through post-transcriptional mechanisms.

Active ribosome profiling with RiboLace

The paper introduces RiboLace, a method to isolate active ribosomes for ribosome profiling, enabling high-resolution analysis of active translation.

In vivo translatome profiling reveals early defects in ribosome biology underlying SMA pathogenesis

The paper identifies early translational defects in SMA mice, showing reduced translational efficiency and ribosome numbers in motor neurons, which are rescued by SMN restoration.