A chimeric, half-life extended lysin with a unique mode of action
Zehra Visram, Donaat Kestemont, Benedikt Bauer, Renping Qiao, Svetlana Ðurica-Mitić, Andrea Majoros-Hashempour, Julia Schmidt, Rocío Berdaguer, Karsten Krey, Michele Mutti, Manuel Zerbs, Marina von Freyberg, Lorenzo Corsini, Adriana Badarau
This paper develops a half-life extended lysin by fusing it to an Fc fragment, showing improved efficacy against staphylococcal infections through targeted release.
Frontiers in Microbiology · Aug 21, 2026Peer-reviewedBioengineering