The Second Mitochondrial Activator of Caspases (SMAC) regulates growth, inflammation and mitochondrial integrity in cancer cells
Tarek Amer, Aladin Haimovici, Susanne Kirschnek, Juliane Vier, Abdul Moeed, Uzochukwu Ukachukwu, Daniela Neugebauer, Philip Neubert, Martin Helmstädter, Séverine Kayser, Rupert Öllinger, Roland Rad, Olaf Groß, Jochen Holzschuh, Wolfgang Driever, , Georg Alexander Häcker
This study identifies SMAC as a regulator of cancer cell growth, inflammation, and mitochondrial integrity, showing its role in both apoptotic and non-apoptotic contexts.
Cell Death and Differentiation · Feb 3, 2026Peer-reviewedCell Biology