Olaf Groß

This study investigates the role of USP8 in B-cell development and multiple myeloma, showing its impact on proteostasis and identifying potential therapeutic strategies.

This study shows NEK7 accelerates NLRP3 inflammasome activation but is not essential, suggesting potential limitations in targeting this interaction for drug development.

This study identifies SMAC as a regulator of cancer cell growth, inflammation, and mitochondrial integrity, showing its role in both apoptotic and non-apoptotic contexts.

This study shows that dual SHP2/MEK inhibition in pancreatic cancer causes mitochondrial changes and ROS elevation, leading to a therapy-resistant state that can be targeted with GPX4 inhibition.

The paper introduces an extended RTF method for modelling dose-dependent kinetics in cellular signalling, demonstrating its effectiveness using inflammasome activation data.