The inflammasome sensor NLRP3 interacts with REV7 to maintain genome integrity through homologous recombination
Delphine Burlet, Md Muntaz Khan, Sabine Hacot, Hannes Buthmann, Léa Bardoulet, Anne‐Laure Huber, Julie Gorry, Bastian Föhr, Bernard S. López, Yohann Couté, Alex C. Faesen, Matthias Geyer, Agnès Tissier, Virginie Pétrilli
This study shows NLRP3 promotes homologous recombination by interacting with REV7, enhancing DNA repair and affecting PARP inhibitor sensitivity.
Nucleic Acids Research · Jun 4, 2025Peer-reviewedMolecular Biology