Author

Alex C. Faesen

Max Planck Institute for Multidisciplinary SciencesORCID 0000-0002-4685-1463Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Agnès TissieriD· 1 shared Anne‐Laure HuberiD· 1 shared Anoshi Patel· 1 shared Bastian Föhr· 1 shared Bernard S. LópeziD· 1 shared Delphine Burlet· 1 shared Gábor NagyiD· 1 shared Hannes ButhmanniD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperMolecular Biology

Agnès TissierORCID

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2 papers

Recent·Most cited

Influence of ULK1 activity on the memory of ATG101 auto-activation dynamics

Anoshi Patel, Sonja Schneider, Gábor Nagy, Olexandr Dybkov, Henning Urlaub, Helmut Grubmüller, Alex C. Faesen

This study investigates how ULK1 activity influences ATG101 auto-activation dynamics, revealing a memory mechanism that accelerates autophagy complex formation.

bioRxiv · Jun 27, 2025 · PreprintBiochemistry

The inflammasome sensor NLRP3 interacts with REV7 to maintain genome integrity through homologous recombination

Delphine Burlet, Md Muntaz Khan, Sabine Hacot, Hannes Buthmann, Léa Bardoulet, Anne‐Laure Huber, Julie Gorry, Bastian Föhr, Bernard S. López, Yohann Couté, Alex C. Faesen, Matthias Geyer, Agnès Tissier, Virginie Pétrilli

This study shows NLRP3 promotes homologous recombination by interacting with REV7, enhancing DNA repair and affecting PARP inhibitor sensitivity.

Nucleic Acids Research · Jun 4, 2025Peer-reviewedMolecular Biology