15-Lipoxygenase-Mediated Lipid Peroxidation Regulates LRRK2 Kinase Activity
Matthew T. Keeney, Eric K. Hoffman, Julie Weir, Weston G. Wagner, Emily M. Rocha, Sandra L. Castro, Kyle Farmer, Marco Fazzari, Roberto Di Maio, Andrei William Konradi, Teresa G. Hastings, Sean A. Pintchovski, William D. Shrader, J. Timothy Greenamyre
This study identifies 15-lipoxygenase-mediated lipid peroxidation as a regulator of LRRK2 kinase activity, linking it to Parkinson's disease pathogenesis.
bioRxiv · Jun 12, 2024 · PreprintNeuroscience