Author

Teresa G. Hastings

University of PittsburghORCID 0000-0002-9034-4944Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 1 Organism:rat· 1

Frequent Co-Authors

Eric K. HoffmaniD· 2 shared J. Timothy GreenamyreiD· 2 shared Kyle FarmeriD· 2 shared Marco FazzariiD· 2 shared Matthew T. KeeneyiD· 2 shared Roberto Di MaioiD· 2 shared Sandra L. CastroiD· 2 shared Alevtina Zharikov· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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2 shared papersNeuroscience

Eric K. HoffmanORCID

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2 papers

Recent·Most cited

15-Lipoxygenase-Mediated Lipid Peroxidation Regulates LRRK2 Kinase Activity

Matthew T. Keeney, Eric K. Hoffman, Julie Weir, Weston G. Wagner, Emily M. Rocha, Sandra L. Castro, Kyle Farmer, Marco Fazzari, Roberto Di Maio, Andrei William Konradi, Teresa G. Hastings, Sean A. Pintchovski, William D. Shrader, J. Timothy Greenamyre

This study identifies 15-lipoxygenase-mediated lipid peroxidation as a regulator of LRRK2 kinase activity, linking it to Parkinson's disease pathogenesis.

bioRxiv · Jun 12, 2024 · PreprintNeuroscience

Neuronal NADPH oxidase in Parkinson disease pathogenesis

Matthew T. Keeney, Eric K. Hoffman, Kyle Farmer, Christopher R. Bodle, Marco Fazzari, Alevtina Zharikov, Sandra L. Castro, Julia K. Kofler, Eugenia Cifuentes-Pagano, Patrick J. Pagano, Edward A. Burton, Teresa G. Hastings, J. Timothy Greenamyre, Roberto Di Maio

The paper demonstrates that neuronal NOX2 contributes to oxidative stress, α-synuclein pathology, and LRRK2 activation in Parkinson's disease and shows that NOX2 inhibitors can prevent these effects in a rat model.

bioRxiv · May 13, 2021 · PreprintNeuroscience