High glucose confers senescence resistance via GLUT1 epigenetic rewiring to blunt immunotherapy responses in esophageal squamous cell carcinoma
Jinxiu Dong, Jie Zhou, Jia‐Jie Hao, Shuai Kong, Chuntong Yin, D M Wei, Fang Wang, Junboya Ma, Jinman Fang, Yuan‐Wei Zhang, 潘华光, Wenqiang Wei, M Wang, Kai Ma, Y Jiang, Yan‐Yi Jiang
This study identifies GLUT1 as a driver of immunotherapy resistance in ESCC by epigenetically suppressing senescence and reveals dietary glucose restriction as a potential strategy to enhance immunotherapy efficacy.
bioRxiv · Jul 16, 2026 · PreprintCancer Biology