Engineering Apical Integrin-binding Cellular Patches to Directed Cell Reprogramming via Mechanical Remodeling
Junchao Zhi, Tianrui Zhao, Wenjing Hou, Qizheng Zhang, Zhen Gao, Jiancan Yu, Kai Wu, Chenjie Xu, Xunwu Hu, Ye Zhang
This paper develops ECM-mimetic cellular patches that reprogram mesenchymal stem cells into neurons through mechanical remodeling without genetic or chemical induction.
bioRxiv · Nov 21, 2025 · PreprintBioengineering